Webinar recording now available: LakePharma’s Coronavirus Spike Protein Antibodies: A fresh quiver of arrows against the crowned invader!
2020-10-01Category: Event
Check out the webinar recording of LakePharma's Coronavirus Spike Protein Antibodies: A quiver of fresh arrows against crowned invader!
Abstract:
As part of
LakePharma's ongoing effort to combat the COVID-19 pandemic, we have discovered
a large collection of over 350 diverse antibodies against the SARS-CoV-2 spike
protein. The SARS-CoV-2 spike protein initiates
viral attachment via binding to human angiotensin-converting enzyme 2 (ACE2),
thus presenting itself as a crucial candidate for COVID-19 therapeutics,
diagnostics, and vaccines.
Following
immunization of our immunologically diverse PentaMiceTM, antibodies
were obtained using our hybridoma-based antibody recovery workflow. Based on extensive screening assays,
LakePharma’s SARS-CoV-2 spike antibodies display a wide range of binding
specificities and functional properties.
The spike antibodies can be grouped according to reactivity profiles
based on binding to the receptor-binding domain (RBD) and/or S1 or S2 domains;
blocking spike protein binding to the ACE2 receptor; neutralizing SARS-CoV-2
pseudovirus infection of ACE2+TMPRSS2+ target cells; and cross-reactivity (or
lack thereof) with spike proteins from other coronaviruses (SARS, MERS, and
HKU1).
The various reactivity and functional profiles are consistent with COVID-19 antibody therapy, prevention of SARS-CoV-2 infection, and selective SARS-CoV-2 detection diagnostics. These antibodies are available for licensing for either therapeutic or diagnostic application. If you are interested in augmenting an existing COVID-19 antibody-based therapeutic or diagnostic program, or jumpstarting an early stage proof-of-concept treatment/prevention/detection paradigm, please join the webinar to learn more.
As part of LakePharma's ongoing effort to combat the COVID-19 pandemic, we have discovered a large collection of over 350 diverse antibodies against the SARS-CoV-2 spike protein. Register now for the free webinar to learn more about LakePharma’s efforts to combat the pandemic.
