Phage and Yeast Display

LakePharma offers phage and eukaryotic-based yeast display platforms for in vitro discovery and engineering of potent antibody candidates for therapeutic or diagnostic use. High-affinity functional antibodies are routinely selected against a wide range of conventional or challenging targets (e.g. GPCRs) using customized or in-licensed state-of-the-art libraries. Multiple antibody scaffolds (llama VHH, scFv, Fab, reformatted IgG) can be delivered upon request. LakePharma's unparalleled in vitro antibody discovery capabilities can be bundled with unique lead optimization, characterization, and downstream large-scale GMP production, therefore providing the entire spectrum of early to late-stage antibody-drug generation services.

Comprehensive service includes:

• Strategy design
• Custom library construction and screening using naïve, semi-synthetic, or immune libraries of scFvs, Fabs or llama VHH
• Primary and secondary functional screens (multiple hits)
  
• Lead antibody characterizations:
  
• Kinetics and epitope binning using Octet® or Carterra® LSA
  
• Ligand blocking
  
• ELISA 
  
• Cell assays

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