Catalog #2000 - Developability Package 2

Title:
Developability Package 2

Description:
Developability Assessment – Package 2

Scope:

1. Polyspecificity Assessment
2. Integrity and Stability Assessment of the concentrated sample

• • Intact mass analysis (reduced and deglycosylated) by mass spectrometry
  • Post-translation modification by mass spectrometry
  • Aggregation analysis by SE-UPLC
  • Purity analysis by CE-SDS
  • Charge variant analysis by cIEF
  • Thermostability analysis by UNcle

3. Accelerated Stress Assessment

• • 3 cycles of Freeze/thaw followed by analytical assays below:
    Aggregation analysis by SE-UPLC
    Purity Analysis by CE-SDS

Deliverable:
Study Report including data deck

Material Required:
Antibody heavy and light chain sequences
1 mg of purified antibody
Project Initiation Fee

Timeline:
3 weeks

Price:
Request