Biotherapeutic antibodies and proteins have the risk of causing anti-drug antibody responses in human bodies and fail to achieve desired therapeutic goals or cause allergic reactions.
Histocompatibility complex class II (MHC class II) are the key molecules to recognize the immunogenic peptides, presented as epitopes from the biotherapeutic molecules, on antigen presenting cells and imprint the T cell receptors for cascade responses.
Our in silico immunogenicity prediction service provides the cost-effective initial analysis of the immunogenicity of the biologics against the major MHC class II alleles. Using trained artificial neural network ensembles, 9 core residues with potential affinity to the binding cleft of MHC class II molecules are identified, providing important information for further engineering and optimization.
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