Post-translational modifications such as glycosylation, deamidation, isomerization, and oxidation have the potential to reduce affinity, potency, stability, and homogeneity of an antibody, resulting in complications in downstream process development. LakePharma has developed algorithms to identify sequences within antibody variable regions that could present potential liabilities to product quality. The sequence liability identification service can help the investigator to assess whether they need to be eliminated early in the engineering process and to select liability free antibodies for further development.
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VH and VL are analyzed for liabilities including, but not limited to, N-linked glycosylation, deamidation, isomerization, pyroglutamate formation, and oxidation.
Amino acid sequence of mature heavy and light chain variable regions
Report identifying potential sequence liabilities