Effector Function Assays - ADCC, CDC, ADCP

LakePharma provides an array of effector function assays to determine activities of candidate antibodies and Fc recombinant proteins:

    1. Antibody-dependent cell-mediated cytotoxicity (ADCC)

    2. Complement-dependent cytotoxicity (CDC)

    3. Antibody-dependent cellular phagocytosis (ADCP)

In addition to functional measurement of antibody activities, LakePharma also has experience in engineering Fc fusion proteins and in testing their binding activities

Please contact LakePharma at inquiries@lakepharma.com for custom quotes and details.

View LakePharma ADCC & CDC case studies.

Cat.# Service Name Timeline Size Price Quantity Request
Custom ADCC assay 2-3 weeks per 96-well plate $3500
Custom CDC assay 2-3 weeks per 96-well plate $2700
Custom ADCP assay Request Request Request

ADCC

    1. Target cells cultured on 96-well plate

    2. Effector cells and test antibodies added

    3. Target cell cytotoxicity measured by LDH, FACS, or label-free target cell specific enzymatic assay

 

 

CDC

    1. Target cells cultured on 96-well plate

    2. Complement and test antibodies added

    3. Target cell cytotoxicity measured by LDH, FACS, or label-free target cell specific enzymatic assay 

1. Test antibodies

2. Target cell line

Study report