Intact Mass Measurement

At LakePharma, we specialize in the Intact Mass analysis of proteins and antibodies. Our strong expertise in antibody development enables us to accurately analyze your antibodies and proteins. This can provide valuable insights to improve your molecule to meet your needs. 

We can help you determine:

       1. Accurate molecular weight of proteins and antibodies 

       2. Approximate glycoprofiling of N-linked oligosaccharides

       3. Approximate assessment of major PTMs 

       4. Approximate assessment of truncations

Please contact us at inquiries@lakepharma.com for your custom quotes and details.

Cat.# Service Name Timeline Size Price Quantity Request
61100 Intact Mass Measurement by LC-MS, reduced 1 week each sample $450
61110 Intact Mass Measurement by LC-MS, reduced & deglycosylated 1 week each sample $550
61120 Intact Mass Measurement by LC-MS, non-reduced 1 week each sample $400
61130 Intact Mass Measurement by LC-MS, non-reduced & deglycosylated 1 week each sample $500

Catalog 61100 & 61110:

Samples are denatured and reduced followed by LC-MS analysis. Samples are also deglycosylated by a PNGase F treatment for catalog 61110.

 

Catalog 61120 & 61130:

Samples are denatured followed by LC-MS analysis. Samples are also deglycosylated by a PNGase F treatment for catalog 61130.

 

Note: the above quoted prices are based on analysis using LakePharma’s standardized methods, proven to work for a majority of antibodies and proteins. Method development may be necessary for atypical proteins with unique properties for an additional fee.

1. 100 ug of purified protein at ≥1 mg/mL

2. Expected molecular weight of target protein

3. (Optional) 10 mL blank buffer formulation

 

Please complete and include a Bioanalytical Sample Submission Form with any proteins or antibodies you send to LakePharma for analysis

Catalog 61100 & 61120
Report with accurate molecular weight determination of reduced or non-reduced samples.

 

Catalog 61110 & 61130
Report with accurate molecular weight determination of reduced or non-reduced samples after deglycosylation.