DNA Assays

Endotoxin or lipopolysaccharide (LPS) is a frequent contaminant of plasmid DNA and protein prepared from bacteria, and can also be present in other purified proteins that have been exposed to traces of bacteria during their production. Endotoxin must be removed from DNA or protein prior to in vivo applications to avoid unwanted inflammatory responses. Endotoxin can be measured with high sensitivity with the limulus amebocyte lysate (LAL) assay, which was accepted by the United States Food and Drug Administration (FDA) in 1983.

Please contact LakePharma at inquiries@lakepharma.com for custom quotes and details.

Cat.# Service Name Timeline Size Price Quantity Request
21700 Endotoxin measurement 3 days per sample $195

1. Endotoxin levels in submitted samples are measured with a chromogenic limulus amebocyte lysate.

2. The assay has a maximum sensitivity of 0.1 EU/mL (Endotoxin Units per milliliter).

Protein or DNA sample

Please complete and include a Sample Submission form with any proteins or antibodies you send to LakePharma for analysis.

Certificate of Analysis