- Molecular Biology
- Viral Vectors & Cell Engineering
- Protein Engineering & Production
- Antibody Discovery & Engineering
- Antibody Production
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Analytics & Formulation
- Overview
- Purity Analysis by CE-SDS
- Aggregation Analysis
- Charge Variant Analysis
- De Novo Antibody Sequencing
- Intact Mass Analysis
- Sequence Confirmation by Mass Spectrometry
- N-terminal Sequencing
- Post-Translational Modification
- N-glycan Analysis
- Thermostability Analysis
- Stability Analysis
- Formulation Development
- Developability Analysis
- R&D and cGxP Bioassay Development
- Protein Chemistry
- Development & Manufacturing in LakePharma Hayward, CA
- Development & Manufacturing in LakePharma Hopkinton, MA
- Consulting Services
Viral Vectors & Cell Engineering
The LakePharma Vector Technology group offers a comprehensive suite of viral vector and cell engineering services, which cover vector engineering, process development, scale-up production, and analytical development. Viral vector platforms include Baculovirus, AAV, and Lentivirus. The cell engineering team performs stable cell line development and clone isolation for production of recombinant proteins utilizing viral transduction and transfection methodologies. The team has experience with a large variety of cell types, including CAR-T, and a host of other cell lines derived from various tissues.
Available Viral Vector Systems
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| - Licensed partner for Oxford Expression Systems flashBAC™, Thermo Fisher Bac-to-Bac®, and Bac-2-the-Future. - BIIC storage - Suspension culture - Rapid high titer production (2 weeks) | - Third generation - Four-plasmid system - HEK293 production | - Baculovirus and mammalian helper-free systems - Adherent and suspension culture |
Comprehensive Viral Vector Services
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| - Vector design - Gene synthesis - Molecular cloning - Plasmid production | - Baculovirus - Mammalian - Adherent and suspension culture - Wave bioreactors (300 L) | - Chromatography: Affinity, IEX, SEC, etc. - Diafiltration - Ultracentrifugation | - AAV vector characterization - Lentivirus vector characterization - Host Cell Protein and DNA - Endotoxin - Bioburden - Mycoplasma |