Protein engineering has greatly benefited from the advent of in vitro display platforms, where an individual or large libraries of peptides or proteins are displayed on the surface of mammalian, yeast, or bacterial cells or even bacteriophage capsids.
Phage vs Yeast Display
Phage display is based on the isolation of large pools of antibody genes cloned into different scaffolds such as antigen-binding fragments (Fab), single-chain variable fragments (scFv), or VHH (nanobody). Yeast display, on the other hand, involves the insertion of a large spectrum of antibody sequences into yeast surface display vectors.
LakePharma offers a variety of libraries
Client Testimonial: Tri-Institutional Therapeutics Discovery Institute and LakePharma: A Partnership in Antibody Discovery to Enable Innovative Therapeutics
Download Infographic: Unique VHH Antibodies from Diverse Yeast & Phage Display Llama Immune Libraries
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Webinar recording: Discovery of Potent, Functional Anti-BTLA, and Anti-TIGIT Monoclonal Antibodies using Hybridoma and Phage Display Platform