Human Ab-Producing Mice
Human-Antibody Producing Rodents
Multiple innovative platforms are currently available for antibody discovery using genetically modified mice that express fully human heavy and light chain variable regions. These animals can generate diverse repertoires of in vivo affinity-matured antibodies with intrinsic drug-like properties necessary for successful development, including high potency, specificity, solubility, and manufacturability. A key advantage is that in having full-human variable regions, the antibodies have a low risk of immunogenicity, thus mitigating efficacy-killing anti-drug responses when reformatted as therapeutics.
Client Testimonial: Tri-Institutional Therapeutics Discovery Institute and LakePharma: A Partnership in Antibody Discovery to Enable Innovative Therapeutics
PentaMice™: A Unique Approach to Achieve Maximum Plasma Titers for Antibody Discovery webinar recording available NOW
Discovery of Potent, Functional Anti-BTLA, and Anti-TIGIT Monoclonal Antibodies using Hybridoma and Phage Display Platform webinar recording available NOW
"LakePharma is nothing short of a true partner with Apollos Diagnostics. We will continue to work with LakePharma as a partner for all of our future antibody development campaigns."
- John Alderete, Ph.D., MBA; Founder and President of Folium Biomed, LLC