Human Ab-Producing Mice
Human-Antibody Producing Rodents
Multiple innovative platforms are currently available for antibody discovery using genetically modified mice that express fully-human heavy and light chain variable regions. These animals can generate diverse repertoires of in vivo affinity-matured antibodies with intrinsic drug-like properties necessary for successful development, including high potency, specificity, solubility, and manufacturability. A key advantage is that in having full-human variable regions, the antibodies have a low risk of immunogenicity, thus mitigating efficacy-killing anti-drug responses when reformatted as therapeutics.
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