Human Ab-Producing Mice

Human-Antibody Producing Rodents

Multiple innovative platforms are currently available for antibody discovery using genetically modified mice that express fully-human heavy and light chain variable regions.  These animals can generate diverse repertoires of in vivo affinity-matured antibodies with intrinsic drug-like properties necessary for successful development, including high potency, specificity, solubility, and manufacturability.  A key advantage is that in having full-human variable regions, the antibodies have a low risk of immunogenicity, thus mitigating efficacy-killing anti-drug responses when reformatted as therapeutics.






Download a free eBook: Introduction to Hybridoma Technologies for Antibody Discovery

PentaMice™: A Unique Approach to Achieve Maximum Plasma Titers for Antibody Discovery webinar recording available NOW

Discovery of Potent, Functional Anti-BTLA, and Anti-TIGIT Monoclonal Antibodies using Hybridoma and Phage Display Platform webinar recording available NOW


"LakePharma is nothing short of a true partner with Apollos Diagnostics. We will continue to work with LakePharma as a partner for all of our future antibody development campaigns."

- John Alderete, Ph.D., MBA; Founder and President of Folium Biomed, LLC
View the testimonial here

"LakePharma is a great partner to work with. Their expertise enables them to generate large panels of antibodies that can be used as the foundation for our therapeutic candidates"

Ronald Herbst, Ph.D., CSO, Pyxis Oncology

View Pyxis clinical pipeline

"LakePharma was a great partner; very helpful, focused, and committed. Thank you for your antibody engineering and production services which made this project a success."

- Maria Day, ImmuNext

View their press release here





References
Lowitz J, Lin G, Somera J, Santibanez-Vargas L, Vo C, Rodriguez E, Nguyen B, Trang M, Nichols J, Kenney J. Optimization of Therapeutic Discovery Strategies for Human Antibody Transgenic Animal Platforms. Poster presented at PEGS; 2019 Apr. 8-12; Boston, MA.Maximizing the AlivaMab Mouse Advantage. Retrieved from https://alivamab.com/alivamab-mouse.