PentaMice



A Proprietary Set of Wildtype Mice Designed to Achieve Maximum Plasma Titers in Hybridoma Campaigns

Conventional immunization approaches utilized in hybridoma-based antibody discovery campaigns typically use one or two common wildtype (WT) mouse strains (e.g. Balb/c or C57Bl/6). LakePharma’s scientists have noted through a course of over 100 campaigns that this approach likely limits the identification of high-quality antibodies to just those target antigens that are efficiently processed and presented by a restricted major histocompatibility complex (MHC) repertoire.

LakePharma’s PentaMice™ Platform is a royalty-free set of mice comprising 5 WT strains that cover 9 distinct MHC haplotypes. A total of 10 mice (2 mice of each strain) are included in each set to achieve maximum plasma titers, thus boosting the opportunity to generate high-quality antibodies in vivo.


The Five Wildtype Strains in the PentaMice Platform


The Concept Behind the PentaMice Platform




Download a free eBook: Introduction to Hybridoma Technologies for Antibody Discovery

PentaMice™: A Unique Approach to Achieve Maximum Plasma Titers for Antibody Discovery webinar recording available NOW!

Discovery of Potent, Functional Anti-BTLA, and Anti-TIGIT Monoclonal Antibodies using Hybridoma and Phage Display Platform webinar recording available NOW!

Click here to learn more about LakePharma hybridoma services or visit hybridoma.com.

Download our Pentamice Flyer by clicking here.